Ligustri Lucidi – nu zhen zi

Ligustrum lucidum (attached: Ligustrum lucidum leaf)
[Family and medicinal part] This product is the mature fruit of Ligustrum lucidum, a plant of Oleaceae.
[Nature and flavor and meridians] Sweet, bitter, flat. Enters the liver and kidney meridians.
[Effects] Nourishes the kidney and nourishes yin, nourishes the liver and improves eyesight.
[Clinical application] Used for liver and kidney deficiency, dizziness, tinnitus, blurred vision, premature graying of hair, etc.
Ligustrum lucidum can nourish the yin of the liver and kidney, and is a clear and tonic medicine. In clinical practice, it is often used in combination with mulberry fruit, Eclipta prostrata, etc., for liver and kidney yin deficiency, dizziness, tinnitus, blurred vision, premature graying of hair, etc.
[Prescription name] Ripe Ligustrum lucidum, Ligustrum lucidum fruit (steamed).
[General dosage and usage] Three to five qian, decocted and taken.
[Attached medicine] Ligustrum lucidum leaf: the leaf of Ligustrum lucidum. Nature and flavor are bitter, slightly sweet and flat. Functions: clearing heat and relieving sore throat. Suitable for symptoms such as sore throat. The general dosage is three to five pieces, washed with cold boiled water, and chewed.
[Comments] 1. According to clinical application experience, the function of nourishing liver and kidney of Ligustrum lucidum is similar to that of Lycium barbarum and Morus alba. However, Lycium barbarum can balance yin and yang, and can be used to treat liver and kidney deficiency, regardless of yin deficiency or yang deficiency; Morus alba can nourish the yin of liver and kidney, and can replenish blood; while Ligustrum lucidum can only nourish yin, not yang, and treat liver and kidney yin deficiency, and has no blood replenishing effect. In general, this medicine is mild in nature, slow in effect, and can only be effective after long-term use.
2. This product is easy to cause laxative bowel if used frequently, such as spleen and stomach deficiency and cold diarrhea, it is not suitable for use.
[Example of prescription] Erzhi Pill “Zhengzhi Zhunsheng”: Ligustrum lucidum, Eclipta prostrata. Treat liver and kidney yin deficiency.
【Literature Excerpt】《本经》: “It tastes bitter and flat, mainly tonifies the middle and calms the five internal organs.”
《本草纲目》: “Strengthens the yin, strengthens the waist and knees, whitens the hair, and brightens the eyes.”
《本草备要》: “Benefits the liver and kidneys, calms the five internal organs, strengthens the waist and knees, brightens the eyes and ears, blackens the hair, and replenishes the wind deficiency.”
This product is the dried mature fruit of Ligustrum lucidum Ait., a plant of the Oleaceae family. Harvested when the fruit is ripe in winter, removes the branches and leaves, slightly steamed or slightly scalded in boiling water, and then dried; or directly dried.
【Properties】
This product is oval, elliptical or kidney-shaped, 6~8.5mm long and 3.5~5.5mm in diameter. The surface is black-purple or gray-black, wrinkled and uneven, with fruit stalk marks or persistent calyx and short stalks at the base. Light body. The exocarp is thin, the mesocarp is relatively soft and easy to peel off, the endocarp is woody, yellow-brown, with longitudinal ridges, and after breaking, there is usually one seed, kidney-shaped, purple-black, and oily. Slight odor, sweet taste, slightly bitter. [Identification]
(1) The powder of this product is gray-brown or black-gray. The cross-section of the epidermal cells (exocarp) of the fruit skin is oblate, the outer wall and side walls are arched and thickened, and the cavity contains yellow-brown substances. The fibers of the endocarp are colorless or light yellow, arranged in several layers above and below, with a diameter of 9~35um. The seed coat cells are scattered with quasi-round secretory cells, light brown, 40~88um in diameter, containing yellow-brown secretions and oil droplets.
(2) Take 0.5g of the powder of this product, add 50ml of dilute ethanol, ultrasonically treat for 30 minutes, filter, and use the filtrate as the test solution. Take 0.5g of Ligustrum lucidum as a control medicinal material and prepare the control medicinal material solution in the same way. According to the thin layer chromatography method (General Rule 0502), 5u of the test solution, 5u of the reference medicinal material solution and 3y of the reference solution under (Content Determination) are respectively spotted on the same brick glue G thin layer plate, and ethyl acetate-acetone-water (5:4:1) is used as the developing agent. Develop, take out, dry, fumigate in iodine vapor until the spots are clear, and inspect under sunlight. In the chromatogram of the test sample, spots of the same color appear at the corresponding positions of the chromatogram of the reference medicinal material and the chromatogram of the reference substance.
【Inspection】
Impurities Not more than 3% (General Rule 2301).
Not more than 8.0% (General Rule 0832 Method 2). Moisture
Total ash content shall not exceed 5.5% (General Rule 2302).
[Extract]
Determine by hot leaching method under the alcohol-soluble extract determination method (General Rule 2201), using 30% ethanol as solvent, and shall not be less than 25.0%.
[Content determination]
Determine by high performance liquid chromatography (General Rule 0512).
Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel is used as filler; methanol-water (40:60) is used as mobile phase; detection wavelength is 224nm. The number of theoretical plates calculated based on the terglucosidol peak should not be less than 4000.
Preparation of reference solution Take an appropriate amount of terglucosidol reference, accurately weigh, and add methanol to make a solution containing 0.25mg per 1ml. Preparation of test solution Take about 0.5g of the powder of this product (pass through No. 3 sieve), weigh it accurately, put it in a stoppered conical bottle, accurately add 50ml of dilute ethanol, weigh it, heat and reflux for 1 hour, cool it, weigh it again, make up the lost weight with dilute ethanol, shake it well, filter it, and take the filtrate to get it.
Determination method: accurately aspirate 5u of the reference solution and 10ml of the test solution respectively, inject it into the liquid chromatograph, and determine it.
This product contains no less than 0.70% of special privet glycoside (C31H42017) calculated on the basis of dry product.
Decoction piece
[Processing]
Ligustrum lucidum removes impurities, washes and dries.
[Properties][Identification][Inspection]
(Water content Total ash)
[Extract][Content determination]
Same as medicinal material.
Ligustrum lucidum wine Take clean Ligustrum lucidum and stew it according to the wine stewing method or wine steaming method (General Rule 0213) until the wine is completely absorbed or steamed through
[Properties]
This product is shaped like Ligustrum lucidum, with a dark brown or grayish black surface, often with white powdery frost. It has a slight aroma of wine.
[Identification]
(2) Take 0.5g of this product powder, add 50ml of dilute ethanol, ultrasonically treat for 30 minutes, filter, and use the filtrate as the test solution. Take the salidroside reference solution under [Content determination], then take the privet glycoside reference solution, add methanol to make a solution containing 0.2 5mg solution, respectively as the reference solution. According to the thin layer chromatography method (general rule 0502), 5μl of the test solution and 5μl of the salidroside reference solution and 34l of the terrigenose reference solution were taken and spotted on the same silica gel G thin layer plate, and ethyl acetate-acetone-water (5:4:1) was used as the developing agent. After development, the plate was taken out, dried, and fumigated in iodine vapor until the spots were clearly colored. In the chromatogram of the test sample, spots of the same color appeared at the corresponding positions of the chromatogram of the reference substance.
[Content determination]
Determined according to the high performance liquid chromatography method (general rule 0512).
Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel was used as the filler; methanol-water (15:85) was used as the mobile phase; the detection wavelength was 275nm. The number of theoretical plates calculated based on the salidroside peak should not be less than 4000.
Preparation of reference solution Take an appropriate amount of salidroside reference substance, weigh it accurately, add 70% methanol to make a solution containing 70ug per 1ml, and obtain the test solution. Take about 0.5g of the powder of this product (passed through a No. 3 sieve), weigh it accurately, put it in a stoppered conical bottle, accurately add 70% methanol 50ml, weigh the weight, ultrasonically treat (power 480W, frequency 40kHz) for 30 minutes, let it cool, weigh it again, make up the lost weight with 70% methanol, shake, filter, and take the filtrate to obtain the solution.
Determination method Accurately aspirate 10u of the reference solution and the test solution respectively, inject them into the liquid chromatograph, and determine the solution.
This product, calculated on the basis of dry product, contains not less than 0.20% salidroside (C14H2007).
[Identification]
(1)
[Inspection]
(Water content, total ash)
[Extract]
Same as medicinal materials. 【Nature and flavor and meridians】
Sweet, bitter, cool. Enters the liver and kidney meridians.
【Functions and indications】
Nourishes the liver and kidney, improves eyesight and darkens hair. Used for liver and kidney yin deficiency, dizziness and tinnitus, soreness of waist and knees, premature graying of hair and beard, blurred vision, internal heat and thirst, bone steaming and hot flashes.
【Usage and dosage】
6~12g.
【Storage】
Put in a dry place.
Where is the main origin of Ligustrum lucidum?
Grows in the mountains and is mostly planted in gardens.
Distributed in East China, South China, Southwest China and Central China. Mainly produced in Zhejiang, Jiangsu, Hunan, Fujian, Guangxi, Jiangxi and Sichuan.
Where is the main medicinal part of Ligustrum lucidum?
Medicinal part of Ligustrum lucidum:
This product is the dried mature fruit of Ligustrum lucidum, a plant of Oleaceae. Harvest when the fruit is ripe in winter, remove the branches and leaves, steam it slightly or scald it in boiling water, and then dry it or dry it directly.
Characteristics of the medicinal part of Ligustrum lucidum:
This product is oval, elliptical or kidney-shaped, 6~8.5mm long and 3.5~5.5mm in diameter.
The surface is black purple or gray-black, wrinkled and uneven, with fruit stalk marks or persistent calyx and short stalks at the base. Light body.
The exocarp is thin, the mesocarp is soft and easy to peel, the endocarp is woody, yellow-brown, with longitudinal ridges, and after breaking, there is usually one seed, kidney-shaped, purple-black, and oily.
The smell is slight, and the taste is sweet and slightly bitter.
How is Ligustrum lucidum recorded in historical books?
“Ben Jing”: “It is mainly used to nourish the middle, calm the five internal organs, nourish the spirit, and eliminate all diseases. Long-term use will make you fat and healthy.
“Ben Cao Meng Quan”: “Black hair and black beard, strong tendons and strength, take more to nourish blood and dispel wind.
“Compendium of Materia Medica·Volume 36”: “Strengthen Yin, strengthen waist and knees, and brighten eyesight.
“Jingyue Complete Book·Compendium of Materia Medica”: “Nourish Yin Qi, calm Yin fire, relieve irritability and bone steaming, stop sweating, and quench thirst… It also clears liver fire and can brighten eyesight and stop tears.
“Compendium of Materia Medica”: “Cool blood and benefit blood.
“New Compendium of Materia Medica”: “Nu Ligustrum lucidum is often used by people nowadays, but its effect is very weak, and it can be used in pills to replenish deficiency.
“Compendium of Materia Medica”: “”Benefits liver and kidney, strengthens waist and knees, and brightens eyes and ears.
Effects
Nu Ligustrum lucidum has the effects of nourishing liver and kidney, brightening eyesight and blackening hair.
What are the main effects and clinical applications of Nu Ligustrum lucidum?
Nu Ligustrum lucidum is used for liver and kidney yin deficiency, dizziness and tinnitus, sore waist and knees, premature graying of hair and beard, dark eyes, internal heat and thirst, and bone steaming and hot flashes.
Liver and Kidney Yin Deficiency
Treats premature graying of hair, blurred vision, dizziness, tinnitus, insomnia, weak waist and knees caused by liver and kidney yin deficiency. It can be used alone or with Eclipta prostrata.
Treats dizziness, insomnia, palpitations, fatigue, low fever or afternoon fever caused by liver and kidney yin deficiency. It can be used together with Angelica sinensis, Rehmannia glutinosa, Eclipta prostrata, etc.
What other effects does Ligustrum lucidum have?
In my country’s traditional food culture, some Chinese medicinal materials are often widely consumed as food ingredients by the people, that is, substances that are both food and Chinese medicinal materials according to tradition (i.e. edible medicinal substances). According to the documents issued by the National Health Commission and the State Administration for Market Regulation, Ligustrum lucidum can be used as both medicine and food within a limited range of use and dosage.
Common medicinal diet recipes for Ligustrum lucidum are as follows:
Weak waist and knees, pain and cramps
400g Ligustrum lucidum, 1.5L of pure wine. Wash Ligustrum lucidum, place it in a clean bottle, soak it with pure wine, open it after 5 days, remove the residue and set aside.
Deficiency of liver and kidney essence and blood, premature graying of hair, hair loss
30g of Ligustrum lucidum, 30g of processed Polygonum multiflorum, 30g of black sesame, 30g of raw Rehmannia root, 30g of raw Platycladus orientalis leaves, 30g of Eclipta prostrata, 9g of Sichuan pepper, 12g of Isatis indigo leaf, 159 of dried orange peel, 500g of black beans.

Decoction the first 9 ingredients twice, remove the residue, combine the medicinal liquid and decoct it into a thin liquid, add black beans (wash first) and cook until the medicinal juice is absorbed, take out the black beans and dry them, and store them in a bottle. Chew 60 pills each time, 3 times a day
Blurred vision (liver and kidney deficiency type)
129 of Ligustrum lucidum, 30g of Lycium barbarum, 12g of Tribulus terrestris, 159 of Plantago seed, 159 of Cuscuta seed, 10g of white chrysanthemum.

Wash and dry the above medicines separately, grind them into coarse powder, mix them evenly, and put them in a bottle for later use. Use 15g of the powder to decoct the soup, cut 90g of pig liver (or sheep liver, chicken liver) into thin slices, add it to the soup and cook or steam it. Add a little salt to taste when taking it, and it can be taken with meals or after meals.
What are the compound preparations containing Ligustrum lucidum?
Erzhi Pills
Nourish the liver and kidney, nourish yin and stop bleeding. Used for liver and kidney yin deficiency, dizziness and tinnitus, dry throat and nose, sore waist and knees, and heavy menstruation.
Nourishing hair growth tablets
Nourish the liver and kidney, replenish qi and nourish the body, and activate the collaterals and promote hair growth. Used for alopecia.
Modern research progress on Ligustrum lucidum
This product has multiple pharmacological effects such as lowering blood sugar, sex hormone-like, improving immunity, delaying aging, lowering blood lipids, and anti-tumor.
Usage method
Ligustrum lucidum has the effect of nourishing the liver and kidney, improving eyesight and blackening hair. Ligustrum lucidum generally uses Ligustrum lucidum slices, which can be taken orally or externally. Please follow the doctor’s advice for specific medication.
How to use Ligustrum lucidum correctly?
When taking Ligustrum lucidum decoction orally, the common dosage is 6~12g.
Ligustrum lucidum can be boiled into ointment for eye drops for external use.
After different processing methods, Chinese herbal medicine slices such as Ligustrum lucidum, Ligustrum lucidum with wine, Ligustrum lucidum with salt and Ligustrum lucidum with vinegar can be produced. It is suitable to be used raw to clear away heat and to be used cooked to nourish the liver and kidney. Wine processing can enhance the effect of nourishing the liver and kidney. Different processing methods have different effects, but the method of use is the same. Please follow the doctor’s advice for specific medication.
Ligustrum lucidum is generally used in decoctions, decoctions are taken, and powders or pills can also be made for consumption. However, the use of Chinese herbal medicines must be differentiated and treated, and should be used under the guidance of professional Chinese medicine practitioners. It should not be used at will, and it is even more forbidden to listen to Chinese medicine prescriptions and advertisements at will.
Common Chinese medicine compatibility is as follows:
Ligustrum lucidum with Eclipta prostrata: Ligustrum lucidum nourishes the liver and kidneys, improves eyesight and blackens hair; Eclipta prostrata nourishes the liver and kidneys, cools blood and clears heat. The two medicines are matched to nourish the liver and kidney and increase the yin power. It is often used to treat liver and kidney yin deficiency.
In addition, Ligustrum lucidum can also be used for daily health care. The common consumption methods are as follows
· Boil water (two-seed chrysanthemum drink): Ligustrum lucidum, wolfberry, chrysanthemum 15g each, boil water and drink. It is used for liver and kidney yin deficiency, dry eyes, blurred vision, or decreased vision.
Soak in wine (Ligustrum lucidum wine): Ligustrum lucidum soaked in wine alone has the effects of nourishing yin and kidney, nourishing liver and improving eyesight. Ligustrum lucidum can also be used with other Chinese medicines to soak in wine, such as mulberry, Rehmannia glutinosa, etc.
How to prepare Ligustrum lucidum?
Ligustrum lucidum
Take the original medicinal material, remove impurities and stems and leaves, wash and dry. Crush it when used. Ligustrum lucidum with wine
Take clean Ligustrum lucidum, mix it with rice wine, simmer it for a while, seal it in a steamer, steam it in a water-proof ditch or other suitable container until the wine is absorbed and the color is dark and moist, then take it out and dry it. Crush it when used. Ligustrum lucidum with wine
Take clean Ligustrum lucidum, mix it with rice wine, and seal it in a steamer after a while. Steam it in a water-proof ditch or other suitable container until the wine is absorbed and the color is dark and moist, then take it out and dry it. Crush it when used. For every 100kg of Ligustrum lucidum, use 20kg of yellow wine.
What drugs should be used with Ligustrum lucidum with special attention?
The combined use of Chinese medicine and Chinese and Western medicine requires syndrome differentiation and individualized clinical treatment. If you are using other drugs, please consult a doctor before taking the medicine, and inform the doctor of all your diagnosed diseases and treatment plans you are receiving.
Medication Instructions
Although Ligustrum lucidum is nourishing but not greasy, it is cold in nature, so it is not suitable for people with spleen and stomach deficiency diarrhea and kidney yang deficiency.
What precautions should be taken when using Ligustrum lucidum?
It is not suitable to take a single medicine in large quantities for a long time for syndromes such as exogenous wind-cold, internal injury, spleen and stomach deficiency, and kidney yang deficiency.
· During the medication period, you should pay attention to avoid eating cold, raw and cold food, spicy and greasy food, and avoid smoking and drinking.
Pregnant and lactating women: If you are pregnant, planning to become pregnant, or are lactating, please inform your doctor in time and consult whether Chinese medicine can be used for treatment.
· Children: Children’s medication must be carried out under the guidance of a doctor and adult supervision.
·Please keep the medicinal materials properly and do not give them to other people.
·Avoid using copper or iron utensils to decoct medicine.
Medication tips
The most frequently asked questions by patients
The harm of taking Ligustrum lucidum frequently
Ligustrum lucidum is cold in nature. It is not suitable to take a large amount of single medicine for a long time for patients with exogenous wind-cold, internal injury, coldness, spleen and stomach deficiency, and kidney yang deficiency. Long-term use of Ligustrum lucidum can cause patients to have symptoms such as dry mouth and diarrhea. Generally, the symptoms will disappear on their own after stopping taking the medicine. When taking Ligustrum lucidum, it should not be taken during menstruation. In order to avoid increased menstrual volume and prolonged menstruation, Ligustrum lucidum should not be taken for too long to prevent liver and kidney damage and endanger health.
How to make Ligustrum lucidum porridge
·Effects: nourishing liver and kidney, improving eyesight and nourishing yin. It is used for dizziness, tinnitus, soreness of waist and knees, premature graying of hair, bone steaming and hot flashes, and blurred vision caused by liver and kidney yin deficiency.
· Raw materials: 15g Ligustrum lucidum, 100g rice, 20g jujube, appropriate amount of sugar.
. Method: Fry the Ligustrum lucidum first, take the supernatant, and add appropriate amount of water. Add rice and jujube, cook into porridge over low heat, and add sugar.
· Usage: Take warm, 1 to 2 times a day. It is not suitable for people with spleen and stomach deficiency and chronic diarrhea.
Is Ligustrum lucidum cool or hot
Ligustrum lucidum The fruit of Ligustrum lucidum is a tonic medicine, which is the dried mature fruit of Ligustrum lucidum, a plant of the Oleaceae family. Ligustrum lucidum is sweet, bitter and cool in nature. It enters the liver and kidney meridians. It has the effects of nourishing the liver and kidneys, improving eyesight and darkening hair. Because Ligustrum lucidum is cold in nature, it is not suitable to take a large amount of single medicine for a long time for symptoms such as exogenous wind-cold, internal injury from raw and cold food, spleen and stomach deficiency and cold, and kidney yang deficiency.